![]() One of the advantages of using cell culture for these applications is the feasibility to manipulate genes and molecular pathways. ![]() In a clinical context, however, cell culture is most commonly linked to creating model systems that study basic cell biology, replicate disease mechanisms, or investigate the toxicity of novel drug compounds. The experimental applications of cultured cells are as diverse as the cell types that can be grown in vitro. Its origin can be found in the early 20th century when it was introduced to study tissue growth and maturation, virus biology and vaccine development, the role of genes in disease and health, and the use of large-scale hybrid cell lines to generate biopharmaceuticals. Cell culture refers to laboratory methods that enable the growth of eukaryotic or prokaryotic cells in physiological conditions.
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